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And Why the Strongest Companies Combine It with Startup Collaboration

 

 

In technology-intensive industries, in-house R&D has never been optional.

It protects intellectual property, enables system integration, ensures reliability, and turns complex technologies into scalable products. Many of today’s market leaders like Bosch and Siemens exist because they invested in R&D long before returns were visible.

That remains true.

What has changed is the speed and fragmentation of technological progress.

Important technologies now develop in many different places at once: universities, startups, suppliers, open-source projects, and related industries. No single company, no matter how large or skilled, can track all of this early enough by itself.

In this environment, the strategic question is not whether internal R&D is critical. It is.

The question is whether internal R&D alone can still provide sufficient foresight, speed, and optionality.

 

 

The Structural Limits of In-House R&D in Technology-Heavy Contexts

 

 

In-house R&D in complex industries is designed for depth, safety, and long-term capability building. It is optimized for robustness, compliance, and scalability.

It is not optimized for early market discovery or fast exploration of uncertain technology paths.

That gap creates predictable limitations.

 

 

 

 

 

1. Time Bias Is Amplified by Complexity

 

In technology-intensive sectors, development cycles are long by necessity.

Hardware dependencies, certification, safety requirements, and system integration stretch timelines. Governance structures exist for good reasons.

But markets, customers, and enabling technologies move faster than internal roadmaps — faster than they have ever moved before.

By the time a new solution is technically mature, the original customer need may have shifted, combined with adjacent technologies, or been redefined entirely.

The result is not failed R&D. It is misaligned timing.

So it can happen that solutions are right but arrive too late.

 

 

2. Technical Excellence Increases Lock-In

 

High-performing R&D teams develop deep attachment to what they build.

That attachment is rational. Complex systems require years of expertise, iteration, and refinement.

But the deeper the investment, the harder it becomes to question the direction.

Early warning signals are often interpreted as integration challenges rather than strategic misalignment. Projects continue because technically they still make sense.

This is how technically sound initiatives survive long after their market relevance has weakened.

 

 

3. Capital-Intensive Bets Reduce Strategic Optionality

 

In technology-heavy industries, R&D investments are large and cumulative.

Once a path is chosen, switching becomes expensive. Not just financially, but organizationally.

Over time, companies unintentionally narrow their future options by committing early to a limited number of technological trajectories.

This creates a dangerous asymmetry:

The cost of continuing feels lower than the cost of changing direction, even when evidence suggests otherwise.

 

 

Why This Does Not Argue Against Strong Internal R&D

 

 

 

None of this suggests weakening internal R&D.

In technology-intensive industries, strong internal R&D is indispensable for:

  • system-level innovation
  • integration of complex technologies
  • long-term differentiation
  • safety, quality, and regulatory compliance
  • scaling beyond prototypes

 

Organizations without deep internal capabilities become dependent on external actors and lose strategic control.

The issue is not internal R&D. The issue is internal R&D operating without external learning loops.

 

 

What Startups Contribute That Corporates Cannot Replicate Internally

 

 

Startups operate under fundamentally different constraints.

They build around narrow problems rather than complete systems. They test assumptions before optimizing solutions. They learn from real usage long before technologies are fully mature.

This makes startups effective sensors for emerging shifts.

Not because they are always right. But because they surface weak signals early.

In technology-intensive industries, those weak signals often determine future winners.

 

 

The Real Value of Startup Collaboration

 

When companies access startups in a structured way, three things happen.

Learning accelerates.

Exploration happens outside the core organization, before large internal commitments are required.

Bias is reduced.

External validation provides reality checks that internal teams cannot generate alone.

Optionality is preserved.

Multiple technology paths can be explored in parallel, without prematurely locking the organization into one direction.

This is not about outsourcing innovation. And it is not about copying startups.

It is about improving strategic decision-making under uncertainty.

 

 

The Companies That Adapt Best Combine Both Worlds

 

Across industrials, energy, mobility, and deep tech, a consistent pattern emerges.

Companies that combine:

  • strong internal R&D for depth and executionwith
  • structured startup collaboration for speed and external learning

adapt earlier and with less disruption than those relying on either approach alone.

They protect R&D from becoming inward-looking. And reduce the cost of being wrong.

 

 

The Leadership Implication

 

For executives in technology-intensive industries, innovation leadership today is about designing an innovation system that can learn faster than competitors.

In-house R&D builds strength and credibility.

Startup collaboration builds awareness, speed, and flexibility.

Together, they reduce the most dangerous risk of all in complex industries:

Realizing too late that the future has already taken shape elsewhere.


Ready to explore how startup collaboration can complement your R&D strategy?

Become an INiTS member and connect with innovative startups that can help your organization stay ahead of technological change. The membership bridges the gap between established companies and emerging ventures, creating the external learning loops that drive strategic advantage.

inits.at/corporates

 

 

In the world of academia, many groundbreaking research results unfortunately never leave the university „drawer“. Lithoz, a spin-off from the TU Wien, serves as a powerful counter-example, having evolved into a „Hidden Champion“ and global market leader in the field of 3D printing for high-performance ceramics.

 

From Dissertation to Innovation

 

Lithoz Standort Wien

The story began in 2006 at TU Wien, where Johannes Homa and Johannes Benedikt conducted research for several years before founding Lithoz in 2011.

Interestingly, while Homa’s initial goal was simply to complete a dissertation, the project gained momentum when industrial partners like Ivoclar expressed interest in the technology being developed at the university.

 

Achieving the Technological Breakthrough

 

The defining challenge for Lithoz was not just making the technology work, but ensuring the 3D-printed parts matched the material properties and strength of conventional manufacturing. Until they reached this milestone, the ceramic parts were too brittle for industrial use.

Their success in achieving industrial-standard strength opened doors to high-stakes applications, including:

  • Aviation: Casting cores for aircraft turbines.
  • Medical Technology: Bone replacement materials, such as cranial implants.
  • Dental: Dental restorations that can withstand the pressure of biting.
  • Industry: Highly stressed machine components and multi-material parts combining ceramic and metal.

Scaling a „Family“ into an Organization

 

Growing from a small founding team to over 100 employees required significant structural adjustments. Homa notes that a company often goes through distinct phases:

  • The 15-Person Stage: At this size, the company still feels like a „family“ where communication happens naturally.
  • The 50-Person Stage: New management levels and structured information flows become essential as a distance develops between the founders and the employees.
  • Constant Adaptation: Lithoz continues to refine its structures, recently implementing medical technology quality standards (ISO 13485) to meet industry requirements.

Lessons in Funding and Sales

 

Lithoz initially chose to grow without outside investors, driven by a misconception that investors were „evil“ or purely exploitative. While this allowed them to avoid immediate dependencies, Homa now views investors as valuable supporters who provide not just capital but also consulting and „time“ to grow faster.

Furthermore, the team had to navigate long sales cycles, which typically last between one and a half to two years for new customers. In this high-tech sector, „sales“ is often synonymous with technical consulting, requiring a balance between creating hype and maintaining absolute honesty about the technology’s current capabilities.

 

Advice for Future Tech Founders

 

Drawing from his experience, Johannes Homa offers three vital tips for those looking to spin off research into a business:

  1. Prioritize Marketing and Sales: Technology is not everything. You cannot assume people will simply know about or buy your product because it is good.
  2. Think Like an Entrepreneur: You must understand the „non-technical“ side, including balance sheets and tax requirements, or hire someone who does.
  3. Hire for Enthusiasm: Place people in roles they are passionate about. A tech-heavy founder should pair with someone who genuinely enjoys the business and sales side.

Ultimately, the path from researcher to CEO is a steep learning curve that requires resilience. As Homa learned, even when a crisis feels like the world is ending (such as a key employee leaving) the world keeps turning, and every problem is an opportunity to find a better solution.

If you want to dive deeper into the full journey listen to the SCALEup Talk podcast episode with Johannes Homa

SCALEup Talk – Lithoz

Deep-tech founders live in two worlds:

the lab, where things behave perfectly under controlled conditions, and the real world, where nothing behaves perfectly.

Most deep-tech projects fail not because the idea is bad, but because the leap from scientific promise to industrial reality is far larger than most teams expect.

There is a simple tool that helps founders stay honest about their progress, brings teams and partners onto the same page, and makes hidden risks visible.

The Technology Readiness Levels (TRLs).

 

1. What TRLs Measure

 

And Why It Matters

TRLs are nothing more than a shared language that says:

“How mature is this technology and how much evidence do we have that it works outside the lab?”

Developed by NASA in the 1970s and standardized later (including in the EU’s Horizon programs), the TRL scale spans 9 levels from a basic idea to a fully proven industrial technology.

Think of it like climbing a mountain:

  • TRL 1: You’ve observed and documented basic principles.
  • TRL 2: You’ve formulated a technology concept or application.
  • TRL 3: You’ve made your first foothold through experimental proof of concept.
  • TRL 4: You’ve validated the technology in a laboratory environment.
  • TRL 5: You’ve validated the technology in a relevant environment.
  • TRL 6: You’ve demonstrated the technology in a relevant environment.
  • TRL 7: You’ve demonstrated the system prototype in an operational environment.
  • TRL 8: The actual system has been completed and qualified through testing and demonstration.
  • TRL 9: The actual system has been proven in an operational environment, which means you are ready for scaling in the real world.

Each level is about evidence you can trust.

 

2. Why TRL Is Essential for Deep-Tech Startups

 

Founders often assume “it works in the lab, so we’re almost ready.”

That assumption is a major trap in deep tech.

Analyses across sectors show that innovations appear stable in labs precisely because labs artificially suppress variability. Conditions can be 8x more stable than industrial environments demand. Real industrial conditions are messy; labs are greenhouses.

TRL forces founders to face this gap early.

TRL asks:

“What have you actually proven? And what remains an assumption?”

This clarity is a communication tool for teams, customers, and investors.

 

3. How TRL Improves Decision-Making

 

TRL turns ambiguity into a sequence of validated checkpoints.

It forces you to ask:

  • What is the one experiment that moves us to the next level?
  • What is the minimum evidence required to reduce risk?

This means:

  • Fewer wasted experiments
  • Fewer emotional bets
  • Sharper prioritization

TRL can improve how investors assess a deep-tech venture, because it turns technical risk into a transparent roadmap rather than a black box. Startups that communicate their maturity this way often find investor conversations more efficient and focused.

Keep in mind: Investors don’t fund ideas. They fund predictability. TRL turns risk into a timeline.

 

4. How to Use TRL as a Strategic Tool

 

TRL needs to live in your daily decisions.

 

1. Internal Alignment

Every team member knows exactly what test, prototype, or validation is required to reach the next level. This dissolves personal preferences and focuses the team on evidence.

2. Customer Conversations

Industrial partners aren’t afraid of risk, they’re afraid of uncertainty. If you can say “we are TRL 5 and here’s how we’ll get to 6,” you turn ambiguity into a shared roadmap.

3. Funding Strategy

Most deep-tech funding follows a pattern that mirrors TRL maturity, even if investors don’t explicitly use the term.

  • Grants and early R&D funding focus on the scientific stages of technology development.
  • Seed and Series A investors typically enter once feasibility and early validation are demonstrated.
  • Growth and strategic capital appear when a system shows stability in near-industrial or industrial conditions.

TRL helps founders target the right type of capital at the right moment by making risk and maturity visible.

 

Conclusion: TRL Is a Mirror

 

TRLs are a reflective tool that answers a deceptively simple question:

“Can this technology handle the weather outside the greenhouse?”

Startups that embrace TRL honestly:

  • make fewer costly mistakes,
  • communicate more clearly, and
  • scale with fewer surprises.

Every technology moves from greenhouse to weather. If you don’t know your TRL, you’re guessing where your risks are. And guessing is the most expensive strategy in deep tech.

TRL helps you see when that transition actually happens.


Want a real-world example of deep-tech maturity in action?

In our SCALEup Talk episode with Johannes Homa from Lithoz (a TU Vienna spin-off), we discuss how breakthrough technology makes the journey from research to industrial deployment.

Watch or listen to the episode here

(The talk is in GERMAN!)

Was passiert, wenn eine wissenschaftliche Entdeckung zu groß ist, um im Labor zu bleiben?

Bei Lithoz führte genau dieser Moment zu einer Entscheidung, die alles verändert hat:
Sie wollten nicht nur publizieren – sie wollten die Industrie revolutionieren.

Heute ist Lithoz ein Hidden Champion im 3D-Druck für Hochleistungskeramik.
Doch der Weg dorthin war alles andere als linear.

In dieser Episode sprechen wir über die Entscheidungen, die man von außen nie sieht, aber die über den Erfolg entscheiden:

– die erste Hypothese, die das gesamte Geschäftsmodell prägte
– wann sich ein Produkt „reif genug“ anfühlt
– wie man eine Labortechnologie industrialisiert, ohne ihren Kern zu verlieren
– warum Lithoz bewusst keine Investor*innen ins Boot geholt hat
– wie man extreme Skepsis überwindet, wenn Technologie als „zu neu“ gilt

und vieles mehr.

Für alle, die Deep Tech nicht nur entwickeln, sondern in die Welt bringen wollen.

🎧 Jetzt reinhören und erfahren, wie aus Forschung ein globales Geschäftsmodell wird:

Website: https://www.lithoz.com/

LinkedIn: https://www.linkedin.com/company/lithoz/
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INiTS Website: https://www.inits.at/
LinkedIn:
https://www.linkedin.com/company/inits/

Für Startup Founder: Jetzt für die Startup Insights anmelden (Updates zu Funding, Tools, Events & Deep-Tech-Gründung) https://www.inits.at/insights/

Mehr über das SCALEup Incubation Program https://www.inits.at/scaleup/

Folge INiTS auf YouTube: https://www.youtube.com/@INiTSVienna

Every December, something strange happens.

Perfectly rational adults suddenly believe that one single day must unfold like a cinematic masterpiece.
The family will get along. The food will be flawless. The gifts will be meaningful. The atmosphere will glow with harmony.

Reality usually answers with burned cookies, last-minute panic, and at least one emotional plot twist.

This mismatch between ideal and reality is not a Christmas problem.
It is a cognitive bias.

Psychologists call it the “expectation gap”, the emotional drop that occurs when the imagined version of an event is so inflated that reality has no chance of living up to it.

Founders run into the same trap.

  • The “perfect launch”.
  • The “explosive growth curve”.
  • The “investor who absolutely must say yes”.

These expectations are often as unrealistic as a Christmas movie plot.
Let’s unpack what founders can learn from Christmas perfectionism and how to set goals that create momentum rather than pressure.

 

Lesson 1:
Perfectionism creates stress. Precision creates progress.

 

Research in organizational psychology shows that unrealistic performance expectations increase cortisol levels and reduce problem-solving accuracy. This explains why stressed teams produce slower decisions and more errors.

Christmas version:
You want a perfect family photo.The kids revolt. The dog escapes. Someone cries. No one smiles.

Startup version:
You want a flawless launch. The server crashes. Your “bug-free” code reveals personality issues. A customer uncovers a use case you never tested.

What actually works:
Set expectations around learning speed, not flawless execution.

The goal of a launch is to generate validated insight. A launch is not a judgment day. It is a data collection event.

When you treat it like an experiment instead of a ceremony, creativity increases and stress decreases.

Practical exercise for founders:
Before every milestone, answer this question:
“What is the minimum useful outcome that would still move us forward?”
This removes perfection from the equation and clarifies your operational reality.

 

Lesson 2:
High expectations without shared context create conflict

 

Families fight at Christmas partly because everyone arrives with a different mental model of “how this should go”.
Startups operate the same way.

A founder imagines rapid traction.
The CTO focuses on reducing technical debt.
Investors expect hockey-stick growth.
Customers want stability.
When left unspoken, these expectations collide.

Research from Harvard’s Negotiation Project shows that misaligned expectations are among the largest contributors to team conflict and slow decision cycles.

What works instead:

Make implicit expectations explicit.
Every quarter, align expectations within your team by asking three questions:

  • What does success look like for each of us this quarter
  • What trade-offs are we willing to accept to achieve it
  • What success metrics will we ignore on purpose

This prevents silent disappointment and clarifies where ambition meets capacity.

 

Lesson 3:
Seeing things too positively clouds your judgment about risks

 

Christmas advertising tells us everything will be beautiful.
Meanwhile, reality includes logistics failure, emotional volatility, and unexpected costs.

Founders do something similar.
They idealize the “post-funding future” or “after we ship this feature everything will be easier”.

Behavioral economics calls this optimism bias, and it is one of the strongest distortions in entrepreneurial decision-making.
Optimism bias is useful for motivation, but dangerous for planning.

Evidence shows that teams who combine optimism with pre-mortem analysis make fewer strategic errors.

A pre-mortem simply asks:

“It is three months from now, and this initiative failed. What went wrong?”

This exercise does two things.

  • It reduces emotional attachment to idealized outcomes.
  • It improves risk identification accuracy.

To compare it to Christmas: if you imagined everything that could realistically go wrong with the dinner ahead of time, you would not panic when the oven rebels. You would have backup plans ready.

Founders benefit from the same mental rehearsal.

 

Lesson 4:
The best moments are rarely the planned ones

 

If you look back at your most memorable Christmas moments, they were usually accidents.
A funny misunderstanding. A small act of kindness. A moment of authenticity.

Startups work the same way.
Major breakthroughs often emerge from unexpected user feedback, accidental discoveries, or side-project experiments.
Many iconic products started this way.

So:

Leave room for serendipity.
Rigid roadmaps suppress innovation. Flexible frameworks invite it.

Maybe you want to use this weekly ritual:
Review what surprised you.
Then ask: “Does this surprise reveal an unmet need or a strategic opportunity?”
Surprise is information. Treat it as data, not disruption.

 

Lesson 5:
Progress needs boundaries, not pressure

 

Christmas comes once a year whether you are ready or not.
Deadlines in startups should work similarly.

A realistic boundary creates progress.
Unrealistic pressure erodes performance.

Evidence from cognitive load theory shows that humans perform best within a zone of optimal stress.

Too little pressure reduces motivation.
Too much pressure impairs working memory, which is fatal in complex problem-solving.

Healthy pressure is specific, time-bound, and directly connected to achievable actions.
Unhealthy pressure is absolute, vague, and fueled by external expectations.

Unhealthy example: “Secure traction before the investor meeting or everything collapses.”
Healthy example: “Talk to ten customers by Friday to understand their purchasing triggers.”

One creates focus. The other creates panic.

 

The founder takeaway:
Expectation management is a strategic skill

 

You cannot eliminate expectations.
But you can learn to manage them in ways that help you move forward instead of holding you back.

Ask yourself this week:

  • Where am I holding on to a “Christmas perfection fantasy” in my startup
  • Where do I expect the impossible
  • Where do I assume harmony without alignment
  • Where do I plan for the ideal instead of the likely
  • Where do I forget that reality always comes with surprises

The founders who master expectation management build more resilient companies.
And they experience less emotional turbulence along the way.

A startup is not Christmas morning.
You are not unwrapping a finished gift.
You are building the gift itself while the world keeps changing the instruction manual.

When you set realistic expectations, keep your team on the same page, think through what could go wrong, and stay open to unexpected opportunities, you’ll build better products. You’ll also save your energy for the long journey of building a startup.

Happy building.
And happy holidays.

Anyone who has worked in an academic environment knows the heartbreak:
A groundbreaking idea gets published… …and then disappears into a drawer.
Not because it’s unimportant, but because tech transfer is structurally difficult.
The founders of Holloid refused to let that happen.

If research can solve real problems, then it shouldn’t stay in the lab.

This mindset shift is essential:

Deep tech is born in the lab. Value is created in the market.

The road between the two is called entrepreneurship.

 

When a Microscope Suddenly Sees Millions Instead of Hundreds

 

Holloid develops 3D holographic microscopy systems roughly the size of a shoebox: compact, unassuming, and capable of producing data that fundamentally changes how we observe the microscopic world.

While traditional microscopes might show you a handful of bacteria, Holloid’s technology reveals millions… …in motion, in interaction, and in real time.
For industries like food safety, pharma, or water processing, this is more than an incremental improvement.
It’s a step change: finally having data that is both immediate and reliable.
This leap is only possible because hardware, software, and algorithmic intelligence are tightly integrated from the ground up.

 

Awards Are Nice. Impact Is Better.

 

Holloid has earned recognition as one of Austria’s most innovative startups, including awards from Trend and Statista.
These accolades help with visibility and talent acquisition, but they’re not the main focus.
As Holloid’s Co-Founder Marcus Lebesmühlbacher emphasizes:

External validation is encouraging, but the real objective is creating meaningful impact; improving value chains, making products safer, processes more stable, and production more efficient.

Solve real problems, and awards tend to follow naturally.

 

 

How to Convince Investors Without Oversimplifying Your Technology

 

A common myth in deep tech:
Investor pitches must oversimplify the technology.
Not true.

Investors don’t fear complexity. They fear mismanaged complexity.

What actually convinces them, according to Markus:

  1. A strong, complementary teamDeep tech is not a solo sport. If one person can “do everything,” something is off.
  2. Market tractionPilot projects, paying customers, and meaningful conversations. Evidence beats narrative every time.

These ingredients helped Holloid secure successful funding rounds and stand out in a crowded landscape.


 

Insights from the Latest SCALEup Talk Episode

 

In our latest SCALEup Talk episode with Marcus Lebesmühlbacher, one message becomes unmistakably clear:

Great research only creates real impact once it leaves the lab and meets the market.

Marcus shares three key lessons for tech founders:

  1. Get to customers early.Validation happens outside the building.
  2. Build a team that functions under pressure.Science and business require different mindsets. Successful teams bridge both.
  3. Protect your agility as you scale.Growth introduces processes and complexity. Hold on to your startup velocity.

If you want deeper insights into Holloid’s journey and practical lessons for your own startup, listen to the full episode here:

👉 SCALEup Talk with Marcus Lebesmühlbacher

For deep-tech founders, Holloid is an example worth studying.

Wie schaffen Founder es, Deep Tech so aufzubauen, dass Kapitalgeber*Innen einsteigen, sich spitzen Teams zusammenfinden und komplexe Forschung zu einem skalierbaren Geschäftsmodell wird?

In dieser Episode spricht Natascha Trzepizur von INiTS mit Marcus Lebesmühlbacher, Co-Founder von Holloid, jenem Startup, das vom Trend und Statista zum innovativsten Startup Österreichs gekürt wurde und die Analyse von Mikroorganismen mit 3D-Holographie neu definiert.

Marcus verrät, was in der Praxis zählt:

◼️ Wie die Auszeichnung als innovativstes Startup die Arbeit verändert
◼️ Welche Faktoren in Finanzierungsrunden ausschlaggebend sind
◼️ Wie Startups trotz Wachstum agil und innovativ bleiben
◼️ Die drei wichtigsten Ratschläge für Tech-Founder

Wenn du ein Tech-Startup aufbaust und wissen willst, wie echte Deep-Tech-Execution aussieht, dann liefert dir dieses Gespräch klare Einsichten und umsetzbare Insights.

————
Folge Marcus Lebesmühlbacher auf LinkedIn:
https://www.linkedin.com/in/lebesmuhlbacher/

Holloid stattet industrielle Produzenten in den Bereichen Pharma, Lebensmittel und Getränke, Chemie, Wasser und Umweltüberwachung mit einem rund um die Uhr verfügbaren, bildbasierten Inline-Monitoring aus. Die KI-gestützte holografische Mikroskopie und IoT-Analytik machen mikroskopische Prozessdaten sichtbar, um Kosten zu senken, Qualität und Sicherheit zu verbessern und eine intelligentere, automatisierte Steuerung zu ermöglichen.

Website: https://www.holloid.com/
LinkedIn: https://www.linkedin.com/company/holloid/

———————————-
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Website: inits.at
LinkedIn: https://www.linkedin.com/company/inits/

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